Molecular motors: a theorist's perspective.

نویسندگان

  • Anatoly B Kolomeisky
  • Michael E Fisher
چکیده

Individual molecular motors, or motor proteins, are enzymatic molecules that convert chemical energy, typically obtained from the hydrolysis of ATP (adenosine triphosphate), into mechanical work and motion. Processive motor proteins, such as kinesin, dynein, and certain myosins, step unidirectionally along linear tracks, specifically microtubules and actin filaments, and play a crucial role in cellular transport processes, organization, and function. In this review some theoretical aspects of motor-protein dynamics are presented in the light of current experimental methods that enable the measurement of the biochemical and biomechanical properties on a single-molecule basis. After a brief discussion of continuum ratchet concepts, we focus on discrete kinetic and stochastic models that yield predictions for the mean velocity, V(F, [ATP], ...), and other observables as a function of an imposed load force F, the ATP concentration, and other variables. The combination of appropriate theory with single-molecule observations should help uncover the mechanisms underlying motor-protein function.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Is Consciousness the Unified Field? A Field Theorist's Perspective

Progress in theoretical physics during the past decade has led to a progressively more unified understanding of the laws of nature, culminating in the recent discovery of completely unified field theories. The parallel discovery of a unified field of consciousness raises fundamental questions concerning the relationship between the two. Following a general introduction to unified quantum field ...

متن کامل

ar X iv : h ep - p h / 03 11 18 8 v 1 14 N ov 2

In this talk I present a summary of some of the discussions at the conference on various topics in Photon physics, selected with a view to give a theorist's perspective, of the current status and future prospects, of the developments in the field. After discussing some of the recent theoretical developments in the subject of Photon Structure function, I will focus on what the photon has helped ...

متن کامل

Stepping and crowding of molecular motors: statistical kinetics from an exclusion process perspective.

Motor enzymes are remarkable molecular machines that use the energy derived from the hydrolysis of a nucleoside triphosphate to generate mechanical movement, achieved through different steps that constitute their kinetic cycle. These macromolecules, nowadays investigated with advanced experimental techniques to unveil their molecular mechanisms and the properties of their kinetic cycles, are im...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Annual review of physical chemistry

دوره 58  شماره 

صفحات  -

تاریخ انتشار 2007